Mitapivat 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP19727CAS号：1260075-17-9纯度：98%

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CAS号	1260075-17-9	货号	BCP19727
关联产品	2329710-91-8（Mitapivat sulfate anhydrous）
中文名	Mitapivat
英文名	Mitapivat
中文别名
英文别名	PKR-IN-1; PKM2 activator 1020; PKM2 activator;AG348;AG-348;AG 348;
SMILES	O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O
化学名称
分子式	C24H26N4O3S	分子量	450.56
纯度	98%	配送	惯例下常温包邮
产品描述	Mitapivat is an orally available, small-molecule, allosteric activator of the red cell isoform of pyruvate kinase (PK-R), with potential to improve hemolytic anemia in patients with pyruvate kinase deficiency (PKD). Upon oral administration, mitapivat binds to and activates PK-R, thereby enhancing glycolytic pathway activity, improving adenosine triphosphate (ATP) levels and reducing 2,3-diphosphoglycerate (2,3-DPG) levels. Mutations in PK-R cause deficiency in PK-R which prevents adequate red blood cell (RBC) glycolysis, leading to a buildup of the upstream glycolytic intermediate 2,3-DPG and deficiency in the PK-R product ATP.