Mitapivat
| CAS号 | 1260075-17-9 | 货号 | BCP19727 |
| 中文名 | Mitapivat | ||
| 英文名 | Mitapivat | ||
| 中文别名 | |||
| 英文别名 | PKR-IN-1; PKM2 activator 1020; PKM2 activator;AG348;AG-348;AG 348; | ||
| 分子式 | C24H26N4O3S | 分子量 | 450.56 |
| 生物活性 | Mitapivat is an orally available, small-molecule, allosteric activator of the red cell isoform of pyruvate kinase (PK-R), with potential to improve hemolytic anemia in patients with pyruvate kinase deficiency (PKD). Upon oral administration, mitapivat binds to and activates PK-R, thereby enhancing glycolytic pathway activity, improving adenosine triphosphate (ATP) levels and reducing 2,3-diphosphoglycerate (2,3-DPG) levels. Mutations in PK-R cause deficiency in PK-R which prevents adequate red blood cell (RBC) glycolysis, leading to a buildup of the upstream glycolytic intermediate 2,3-DPG and deficiency in the PK-R product ATP. | ||
| 上下游产品 | 2329710-91-8（Mitapivat sulfate anhydrous） | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Pyruvate Kinase | ||
结构式
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