即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 1221186-53-3 | 货号 | BCP12877 |
中文名 | ML265 | ||
英文名 | ML265 | ||
中文别名 | |||
英文别名 | ML 265;ML-265;TEPP-46;TEPP 46;TEPP46; CID44246499; CID-44246499; CID 44246499; NCGC00186528; NCGC 00186528; NCGC-00186528; | ||
SMILES | O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4 | ||
化学名称 | |||
分子式 | C17H16N4O2S2 | 分子量 | 372.46 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ML265 is a potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model. Cancer cells have altered metabolic processes compared to normal differentiated cells and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this aberrant metabolism. ML265 induces the more active tetrameric state of PKM2 and the X-ray co-crystal structure shows that the activator binds at the dimer-dimer interface between two subunits of PKM2. ML265 was tested in a H1299 mouse xenograft model and showed significant reduction in tumor size, weight, and occurrence with no apparent toxicity over the 7-week experiment. |
Tags:ML265 供应商,ML265 购买,ML265 生产,ML265 批量,ML265 供应,ML265 订购,ML265 采购