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MK-7145 结构式

MK-7145

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货号 :BCP38355CAS号 :1255204-84-2纯度:98%
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  • 基本信息与产品描述
CAS号 1255204-84-2 货号 BCP38355
中文名 MK-7145
英文名 MK-7145
中文别名
英文别名 MK 7145; MK7145;
SMILES CC1=C(C=CC2=C1COC2=O)C(CN3CCN(CC3)CC(C4=C(C5=C(C=C4)C(=O)OC5)C)O)O
化学名称
分子式 C26H30N2O6 分子量 466.53
纯度 98% 配送 惯例下常温包邮
产品描述 MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). MK-7145 was not a potent reversible inhibitor of human CYP3A4, CYP2C9, or CYP2D6 (IC50 > 50μM) and was not a time-dependent inhibitor of CYP3A4 at 10and 50 μM. MK-7145 caused dose-dependent lowering of blood pressure in a subchronic SHR model. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development.
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