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CAS号 | 122320-73-4 | 货号 | BCP03047 |
中文名 | 罗格列酮 | ||
英文名 | Rosiglitazone | ||
中文别名 | |||
英文别名 | Avandia;BRL-49653;BRL 49653;BRL49653; HSDB 7555; HSDB-7555; HSDB7555; TDZ 01; TDZ-01; TDZ01; | ||
SMILES | |||
化学名称 | |||
分子式 | C18H19N3O3S | 分子量 | 357.43 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Rosiglitazone (Avandia) has recently been identified as a high-affinity ligand for PPARγ, a nuclear hormone receptor that is abundantly expressed in adipocytes and plays a central role as a regulator of terminal adipocyte differentiation. Rosiglitazone (Avandia) acts primarily by increasing insulin sensitivity. Rosiglitazone (Avandia) improves glycemic control while reducing circulating insulin levels. Rosiglitazone (Avandia) is a member of the thiazolidinedione class of drugs. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). Thiazolidinediones enter the cell, bind to the nuclear receptors, and affect the expression of DNA. Rosiglitazone (Avandia, BRL-49653) also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance. |
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