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| CAS号 | 847871-99-2 | 货号 | BCP25399 |
| 中文名 | 来那度胺半水合物 | ||
| 英文名 | Lenalidomide hemihydrate | ||
| 中文别名 | |||
| 英文别名 | CC-5013 hemihydrate;CC 5013 hemihydrate;CC5013 hemihydrate; | ||
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N.C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N.O | ||
| 化学名称 | |||
| 分子式 | C26H28N6O7 | 分子量 | 536.55 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Lenalidomide hemihydrate, a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells. | ||
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