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Vedolizumab 结构式

维多珠单抗

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货号 :BCP26256CAS号 :943609-66-3纯度:98%
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  • 基本信息与产品描述
CAS号 943609-66-3 货号 BCP26256
中文名 维多珠单抗
英文名 Vedolizumab
中文别名
英文别名 MLN-02; LDP-02; MLN0002;Anti-Human lymphocyte α4β7 integrin, Humanized Antibody;
SMILES
化学名称
分子式 C6528H10072N1732O2042S42 分子量 146834.53
纯度 98% 配送 惯例下常温包邮
产品描述 Vedolizumab is a monoclonal antibody binds to integrin α4β7. Vedolizumab blocks the α4β7 integrin, results in gut-selective anti-inflammatory activity. Vedolizumab binds to memory CD4(+) T and B lymphocytes with subnanomolar potency (EC(50) = 0.3-0.4 nM). Vedolizumab also binds to eosinophils at high levels, and to naive T-helper lymphocytes, naive and memory cytotoxic T lymphocytes, B lymphocytes, natural killer cells, and basophils at lower levels. Vedolizumab selectively inhibits adhesion of alpha(4)beta(7)-expressing cells to mucosal addressin cell adhesion molecule 1 (median inhibition concentration [IC(50)] = 0.02-0.06 microg/ml) and fibronectin (IC(50) = 0.02 microg/ml), but not vascular cell adhesion molecule.
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