维多珠单抗

  • 化学数据
CAS号 943609-66-3 货号 BCP26256
中文名 维多珠单抗
英文名 Vedolizumab
中文别名
英文别名 MLN-02; LDP-02; MLN0002;Anti-Human lymphocyte α4β7 integrin, Humanized Antibody;
分子式 C6528H10072N1732O2042S42 分子量 146834.53
  • 用途
生物活性 Vedolizumab is a monoclonal antibody binds to integrin α4β7. Vedolizumab blocks the α4β7 integrin, results in gut-selective anti-inflammatory activity. Vedolizumab binds to memory CD4(+) T and B lymphocytes with subnanomolar potency (EC(50) = 0.3-0.4 nM). Vedolizumab also binds to eosinophils at high levels, and to naive T-helper lymphocytes, naive and memory cytotoxic T lymphocytes, B lymphocytes, natural killer cells, and basophils at lower levels. Vedolizumab selectively inhibits adhesion of alpha(4)beta(7)-expressing cells to mucosal addressin cell adhesion molecule 1 (median inhibition concentration [IC(50)] = 0.02-0.06 microg/ml) and fibronectin (IC(50) = 0.02 microg/ml), but not vascular cell adhesion molecule.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 Integrin 

结构式

本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
全国免费电话:400-099-8200
在线客服:
技术支持:
orders@biochempartner.com
瀚香官网:
www.biochempartner.com
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!