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CAS号 | 90566-53-3 | 货号 | BCP31287 |
中文名 | 氟替卡松 | ||
英文名 | Fluticasone | ||
中文别名 | |||
英文别名 | Fluticasonum; | ||
SMILES | CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)O)C)O)F)C)F | ||
化学名称 | |||
分子式 | C22H27F3O4S | 分子量 | 444.51 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Fluticasone is a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. |
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