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Fluocinolone 结构式

氟轻松

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货号 :BCP36573CAS号 :807-38-5纯度:98%
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  • 基本信息与产品描述
CAS号 807-38-5 货号 BCP36573
中文名 氟轻松
英文名 Fluocinolone
中文别名
英文别名 6-alpha-Fluorotriamcinolone;
SMILES CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CC(C4=CC(=O)C=CC43C)F)F)O
化学名称
分子式 C21H26F2O6 分子量 412.42
纯度 98% 配送 惯例下常温包邮
产品描述 Fluocinolone is a synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.
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