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CAS号 | 807-38-5 | 货号 | BCP36573 |
中文名 | 氟轻松 | ||
英文名 | Fluocinolone | ||
中文别名 | |||
英文别名 | 6-alpha-Fluorotriamcinolone; | ||
SMILES | CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CC(C4=CC(=O)C=CC43C)F)F)O | ||
化学名称 | |||
分子式 | C21H26F2O6 | 分子量 | 412.42 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Fluocinolone is a synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis. |
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