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Paroxetine maleate 结构式

马来酸帕罗西汀

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货号 :BCP29366CAS号 :64006-44-6纯度:98%
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  • 基本信息与产品描述
CAS号 64006-44-6 货号 BCP29366
中文名 马来酸帕罗西汀
英文名 Paroxetine maleate
中文别名
英文别名 Paroxetine maleate salt;FG 7051 maleate;
SMILES C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C(=CC(=O)O)C(=O)O
化学名称
分子式 C19H20NO3F.C4H4O4 分子量 445.44
纯度 98% 配送 惯例下常温包邮
产品描述 Paroxetine maleate is a maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. It has a role as an antidepressant, an anxiolytic drug, a serotonin uptake inhibitor, a hepatotoxic agent and a P450 inhibitor. It contains a paroxetinium(1+).
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