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AV-412 Tosylate 结构式

AV-412 Tosylate

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货号 :BCP23783CAS号 :451493-31-5纯度:98%
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  • 基本信息与产品描述
CAS号 451493-31-5 货号 BCP23783
中文名 AV-412 Tosylate
英文名 AV-412 Tosylate
中文别名
英文别名 MP-412; MP 412; MP412; AV-412; AV 412; AV412;
SMILES O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O
化学名称
分子式 C41H44ClFN6O7S2 分子量 851.41
纯度 98% 配送 惯例下常温包邮
产品描述 AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.
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