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CAS号 | 451493-31-5 | 货号 | BCP23783 |
中文名 | AV-412 Tosylate | ||
英文名 | AV-412 Tosylate | ||
中文别名 | |||
英文别名 | MP-412; MP 412; MP412; AV-412; AV 412; AV412; | ||
SMILES | O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O | ||
化学名称 | |||
分子式 | C41H44ClFN6O7S2 | 分子量 | 851.41 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. |
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