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NPS 2143 结构式

NPS 2143

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货号 :BCP02421CAS号 :284035-33-2纯度:98%
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  • 基本信息与产品描述
CAS号 284035-33-2 货号 BCP02421
中文名 NPS 2143
英文名 NPS 2143
中文别名
英文别名 NPS-2143;NPS2143;SB-262470;SB 262470;SB262470;
SMILES
化学名称
分子式 C24H25ClN2O2 分子量 408.92
纯度 98% 配送 惯例下常温包邮
产品描述 NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation. In HEK-293 cells transiently expressing hCaSRs, NPS 2143 significantly suppresses the kokumi taste by effectively inhibiting the activity of both GSH (data not shown) and γ-Glu-Val-Gly. A recent study shows that NPS 2143 treatment suppresses low molecular weight fractions of azuki hydrolysate-induced cholecystokinin (CCK) secretion in CaSR-transfected HEK 293 cells.
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