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Riluzole 结构式

利鲁唑

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货号 :BCP02142CAS号 :1744-22-5纯度:98%
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  • 基本信息与产品描述
CAS号 1744-22-5 货号 BCP02142
中文名 利鲁唑
英文名 Riluzole
中文别名
英文别名 Rilutek;
SMILES
化学名称
分子式 C8H5F3N2OS 分子量 234.2
纯度 98% 配送 惯例下常温包邮
产品描述 Riluzole inhibits the release of glutamic acid from cultured neurons, and from brain slices. These effects may be partly due to inactivation of voltage-dependent sodium channels on glutamatergic nerve terminals, as well as activation of a G-protein-dependent signal transduction process. Electrophysiologic experiments performed on isolated excitatory amino acid receptors expressed in the Xenopus oocyte have revealed that Riluzole inhibits currents evoked by N-methyl-D-aspartate (NMDA) (IC50 = 18 μM) and kainic acid (IC50 = 167 μM). Riluzole has been shown to stabilize inactivated sodium channels in frog sciatic nerve, in rat cerebellar granule cells, and on recombinant rat sodium channels expressed in Xenopus oocytes (Ki = 0.2 μM). Riluzole also blocks some of the postsynaptic effects of glutamic acid by noncompetitive blockade of NMDA receptors. Tiluzole protects cultured neurons from anoxic damage, from the toxic effects of glutamic-acid-uptake inhibitors, and from the toxic factor in
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