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CAS号 | 256376-24-6 | 货号 | BCP16012 |
中文名 | BAY 41-2272 | ||
英文名 | BAY 41-2272 | ||
中文别名 | |||
英文别名 | BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272; | ||
SMILES | C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F | ||
化学名称 | |||
分子式 | C20H17FN6 | 分子量 | 360.39 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BAY 41-2272 is a a soluble guanylate cyclase stimulator (sGC stimulator). BAY 41-2272 inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo. BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats. |
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