GNF2133 HCl 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP45493CAS号：2561414-57-9纯度：98%

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CAS号	2561414-57-9	货号	BCP45493
中文名	GNF2133 HCl
英文名	GNF2133 HCl
中文别名
英文别名	GNF2133 hydrochloride; GNF-2133 HCl; GNF 2133 HCl;
SMILES	CCN1CCN(CC1)C(=O)NC2=NC=CC(=C2)C3=CN(C4=C3C=CN=C4)C5CCOCC5.Cl
化学名称
分子式	C24H31ClN6O2	分子量	471.0
纯度	98%	配送	惯例下常温包邮
产品描述	GNF2133 hydrochloride is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 hydrochloride shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 hydrochloride significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 hydrochloride has the potential for the research of type 1 diabetes.GNF2133 is a potent and selective DYRK1A inhibitor (IC50 = 6 nM). In vitro, GNF2133 is able to proliferate both rodent and human β-cells. In vivo, GNF2133 demonstrated significant dose-dependent glucose disposal capacity and insulin secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) challenge in rat insulin promoter and diphtheria toxin A (RIP-DTA) mice.