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CAS号 | 1594092-37-1 | 货号 | BCP12820 |
中文名 | AZ191 | ||
英文名 | AZ191 | ||
中文别名 | |||
英文别名 | AZ-191;AZ 191; | ||
SMILES | |||
化学名称 | |||
分子式 | C24H27N7O | 分子量 | 429.52 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Using in vitro kinase assays, phospho-specific immunoblot analysis and MS in conjunction with AZ191 we now show that DYRK1B phosphorylates CCND1 at Thr(286), not Thr(288), in vitro and in cells. In HEK (human embryonic kidney)-293 and PANC-1 cells (which exhibit DYRK1B amplification) DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 and this is abolished by AZ191 or DYRK1B RNAi, but not by GSK3β inhibitors or GSK3β RNAi. |
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