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CAS号 | 2331255-53-7 | 货号 | BCP47152 |
中文名 | ABC99 | ||
英文名 | ABC99 | ||
中文别名 | |||
英文别名 | ABC-99; ABC 99; | ||
SMILES | C1CN2C(CN1CC3=CC=C(C=C3)Cl)C(=O)N(C2=O)OC(=O)N4CCOC5=CC=CC=C54 | ||
化学名称 | |||
分子式 | C22H21ClN4O5 | 分子量 | 456.88 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ABC99 is a Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme, ABC99 inhibited NOTUM with an IC50 value of 13 nM and showed excellent selectivity across the serine hydrolase family, as initially assessed by gel-based ABPP of soluble and membrane proteomes from SW620 cells. ABC99 preserves Wnt-mediated cell signaling in the presence of NOTUM and was also converted into an ABPP probe for visualizing NOTUM in native biological systems. |
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