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CAS号 | 165668-41-7 | 货号 | BCP06110 |
中文名 | Indisulam | ||
英文名 | Indisulam | ||
中文别名 | |||
英文别名 | E7070; E 7070; E-7070; ER35744; ER 35744; ER-35744; D04522; | ||
SMILES | |||
化学名称 | |||
分子式 | C14H12ClN3O4S2 | 分子量 | 385.85 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Indisulam, also known as E7070, is a carbonic anhydrase inhbitor, is also a novel synthetic sulfonamide that targets the G1 phase of the cell cycle. The potential antitumor activity of Indisulam was discovered through optimization of the structure-activity relationships of a series of sulfonamide structures. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E. Preclinical studies with Indisulam showed activity in multiple tumor types, most prominently in colon and lung cancer. |
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