Indisulam

  • 化学数据
CAS号 165668-41-7 货号 BCP06110
中文名 Indisulam
英文名 Indisulam
中文别名
英文别名 E7070; E 7070; E-7070; ER35744; ER 35744; ER-35744; D04522;
分子式 C14H12ClN3O4S2 分子量 385.85
  • 用途
生物活性 Indisulam, also known as E7070, is a carbonic anhydrase inhbitor, is also a novel synthetic sulfonamide that targets the G1 phase of the cell cycle. The potential antitumor activity of Indisulam was discovered through optimization of the structure-activity relationships of a series of sulfonamide structures. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E. Preclinical studies with Indisulam showed activity in multiple tumor types, most prominently in colon and lung cancer.
信号通路 Protease/Metabolic Enzyme 
靶 点 Carbonic Anhydrase 

结构式

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