S55746 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP39114CAS号：1448584-12-0纯度：98%

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CAS号	1448584-12-0	货号	BCP39114
中文名	S55746
英文名	S55746
中文别名
英文别名	BCL201; BCL-201; BCL 201; S-55746; S 55746; Servier-1;
SMILES	C1CCN2C(=C(C=C2C3=CC4=C(C=C3C(=O)N5CC6=CC=CC=C6CC5CN7CCOCC7)OCO4)C(=O)N(C8=CC=CC=C8)C9=CC=C(C=C9)O)C1
化学名称
分子式	C43H42N4O6	分子量	710.82
纯度	98%	配送	惯例下常温包邮
产品描述	S55746 is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. S55746 potently impairs hematological tumor growth. S55746 occupies the hydrophobic groove of BCL-2. S55746 induces hallmarks of apoptosis including externalization of phosphatidylserine, caspase-3 activation and PARP cleavage. Ex vivo, S55746 induces apoptosis in the low nanomolar range in primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma patient samples.