S55746
| CAS号 | 1448584-12-0 | 货号 | BCP39114 |
| 中文名 | S55746 | ||
| 英文名 | S55746 | ||
| 中文别名 | |||
| 英文别名 | BCL201; BCL-201; BCL 201; S-55746; S 55746; Servier-1; | ||
| 分子式 | C43H42N4O6 | 分子量 | 710.82 |
| 生物活性 | S55746 is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. S55746 potently impairs hematological tumor growth. S55746 occupies the hydrophobic groove of BCL-2. S55746 induces hallmarks of apoptosis including externalization of phosphatidylserine, caspase-3 activation and PARP cleavage. Ex vivo, S55746 induces apoptosis in the low nanomolar range in primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma patient samples. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Bcl2 | ||
结构式
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