依克立达新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP05709CAS号：143664-11-3纯度：98%

在线咨询

购买咨询

全国免运费！免费咨询：400-099-8200 或手机联系：13472751340

* 必填项

请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS号	143664-11-3	货号	BCP05709
中文名	依克立达
英文名	Elacridar
中文别名
英文别名	GF120918; GF-120918; GF 120918; GW 0918;GW-0918;GW0918; GG918;GG 918;GG-918; GF-120918; GF 120918;
SMILES
化学名称
分子式	C34H33N3O5	分子量	563.64
纯度	98%	配送	惯例下常温包邮
产品描述	Elacridar is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.

依克立达 新