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CAS号 | 1262108-14-4 | 货号 | BCP24069 |
中文名 | Vilaprisan | ||
英文名 | Vilaprisan | ||
中文别名 | |||
英文别名 | BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670; | ||
SMILES | C[C@@](C[C@@H]1C2=CC=C(S(C)(=O)=O)C=C2)([C@]3(O)C(F)(F)C(F)(F)F)[C@](CC3)([H])[C@@](CC4)([H])C1=C(CC5)C4=CC5=O | ||
化学名称 | |||
分子式 | C27H29F5O4S | 分子量 | 544.58 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Vilaprisan, also known as BAY1002670 or BAY10-02670, is a potent and selective oral progesterone receptor modulator that holds the promises of long-term treatment of patients with symptomatic uterine fibroids. BAY1002670 in subnanomolar concentrations exhibits a highly selective binding profile and antagonistic activity for the PR. These properties are also reflected in its action in two progesterone-dependent animal models that assess the termination of pregnancy and endometrial transformation. In a human fibroid xenograft model BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005). |
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