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Vilaprisan

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货号 :BCP24069CAS号 :1262108-14-4纯度:98%
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  • 基本信息与产品描述
CAS号 1262108-14-4 货号 BCP24069
中文名 Vilaprisan
英文名 Vilaprisan
中文别名
英文别名 BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670;
SMILES C[C@@](C[C@@H]1C2=CC=C(S(C)(=O)=O)C=C2)([C@]3(O)C(F)(F)C(F)(F)F)[C@](CC3)([H])[C@@](CC4)([H])C1=C(CC5)C4=CC5=O
化学名称
分子式 C27H29F5O4S 分子量 544.58
纯度 98% 配送 惯例下常温包邮
产品描述 Vilaprisan, also known as BAY1002670 or BAY10-02670, is a potent and selective oral progesterone receptor modulator that holds the promises of long-term treatment of patients with symptomatic uterine fibroids. BAY1002670 in subnanomolar concentrations exhibits a highly selective binding profile and antagonistic activity for the PR. These properties are also reflected in its action in two progesterone-dependent animal models that assess the termination of pregnancy and endometrial transformation. In a human fibroid xenograft model BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005).
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