Vilaprisan
CAS号 | 1262108-14-4 | 货号 | BCP24069 |
中文名 | Vilaprisan | ||
英文名 | Vilaprisan | ||
中文别名 | |||
英文别名 | BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670; | ||
分子式 | C27H29F5O4S | 分子量 | 544.58 |
生物活性 | Vilaprisan, also known as BAY1002670 or BAY10-02670, is a potent and selective oral progesterone receptor modulator that holds the promises of long-term treatment of patients with symptomatic uterine fibroids. BAY1002670 in subnanomolar concentrations exhibits a highly selective binding profile and antagonistic activity for the PR. These properties are also reflected in its action in two progesterone-dependent animal models that assess the termination of pregnancy and endometrial transformation. In a human fibroid xenograft model BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005). | ||
信号通路 | Hormone Pathay | ||
靶 点 | Progesterone Receptor |
结构式
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