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| CAS号 | 1227163-84-9 | 货号 | BCP23892 |
| 中文名 | AZD3839 | ||
| 英文名 | AZD3839 | ||
| 中文别名 | |||
| 英文别名 | AZD-3839; AZD 3839; | ||
| SMILES | FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1 | ||
| 化学名称 | |||
| 分子式 | C24H16F3N5 | 分子量 | 431.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AZD3839 is a potent and selective BACE1 inhibitor. AZD3839 is clinical candidate for the treatment of Alzheimer disease. AZD3839 inhibits BACE1 activity, Aβ and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons. Selectivity against BACE2 and cathepsin D was 14 and >1000-fold, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. | ||
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