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Torin 2 结构式

Torin 2

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP02612CAS号 :1223001-51-1纯度:98%
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  • 基本信息与产品描述
CAS号 1223001-51-1 货号 BCP02612
中文名 Torin 2
英文名 Torin 2
中文别名
英文别名 Torin2; Torin-2;
SMILES C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
化学名称
分子式 C24H15F3N4O 分子量 432.4
纯度 98% 配送 惯例下常温包邮
产品描述 Torin 2 has the same binding mode as PI3Kγ, V882 serves as a hinge binding point and in the inner hydrophobic pocket Y867, D841 and D964 provide three more hydrogen bonds with aminopyridine side chain analogous to Y2225, D2195 and D2357 of mTOR.Torin 2 inhibits mTORC1, thus activates TFEB by promoting its nuclear translocation with EC50 of 1.666 mM.Torin 2(< 50 nM) causes a significant reduction in viability of both MZ-CRC-1 and TT cells. Torin 2 (100 nM) exerts a significant reduction of migration of both MZ-CRC-1 and TT cells.
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