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CAS号 | 2803881-11-8 | 货号 | BCP49710 |
中文名 | MRT-2359 | ||
英文名 | MRT-2359 | ||
中文别名 | |||
英文别名 | MRT2359;MRT 2359; | ||
SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=C(C=C3)COC(=O)NC4=C(C=CC(=C4)OC(F)(F)F)F | ||
化学名称 | |||
分子式 | C22H17F4N3O6 | 分子量 | 495.38 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research. |
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