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CAS号 | 120202-66-6 | 货号 | BCP06463 |
中文名 | 硫酸氯吡格雷 | ||
英文名 | Clopidogrel hydrogen sulfate | ||
中文别名 | |||
英文别名 | Clopidogrel sulfate;(S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate; | ||
SMILES | |||
化学名称 | |||
分子式 | C16H18ClNO6S2 | 分子量 | 419.89 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Clopidogrel is an effective antiplatelet agent useful for the treatment of ischemic cerebrovascular, cardiac, and peripheral arterial disease. Clopidogrel abolishes the inhibitory P2Y(AC) receptor-mediated ADP effects on prostaglandin E(1)-stimulated, cAMP-dependent phosphorylation of VASP without affecting epinephrine, thrombin, and thromboxane signaling. VASP phosphorylation is known to be closely correlated with the inhibition of platelet and fibrinogen receptor (glycoprotein IIb/IIIa) activation. Therefore, inhibition of the platelet P2Y(AC) ADP receptor and its intracellular signaling, including decreased VASP phosphorylation, is suggested as a molecular mechanism of clopidogrel action. Clopidogrel ingestion reduced the thrombus volume significantly (p < 0.05) at 100 and 2600 s-1 (39 and 51% respectively). clopidogrel reduced significantly the fibrinopeptide A plasma levels and the fibrin deposition at shear rates below 650 s-1 . |
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