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Clopidogrel hydrogen sulfate 结构式

硫酸氯吡格雷

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货号 :BCP06463CAS号 :120202-66-6纯度:98%
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  • 基本信息与产品描述
CAS号 120202-66-6 货号 BCP06463
中文名 硫酸氯吡格雷
英文名 Clopidogrel hydrogen sulfate
中文别名
英文别名 Clopidogrel sulfate;(S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate;
SMILES
化学名称
分子式 C16H18ClNO6S2 分子量 419.89
纯度 98% 配送 惯例下常温包邮
产品描述 Clopidogrel is an effective antiplatelet agent useful for the treatment of ischemic cerebrovascular, cardiac, and peripheral arterial disease. Clopidogrel abolishes the inhibitory P2Y(AC) receptor-mediated ADP effects on prostaglandin E(1)-stimulated, cAMP-dependent phosphorylation of VASP without affecting epinephrine, thrombin, and thromboxane signaling. VASP phosphorylation is known to be closely correlated with the inhibition of platelet and fibrinogen receptor (glycoprotein IIb/IIIa) activation. Therefore, inhibition of the platelet P2Y(AC) ADP receptor and its intracellular signaling, including decreased VASP phosphorylation, is suggested as a molecular mechanism of clopidogrel action. Clopidogrel ingestion reduced the thrombus volume significantly (p < 0.05) at 100 and 2600 s-1 (39 and 51% respectively). clopidogrel reduced significantly the fibrinopeptide A plasma levels and the fibrin deposition at shear rates below 650 s-1 .
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