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GSK-189254 hydrochloride 结构式

GSK-189254 hydrochloride

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货号 :BCP23443CAS号 :945493-87-8纯度:98%
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  • 基本信息与产品描述
CAS号 945493-87-8 货号 BCP23443
中文名 GSK-189254 hydrochloride
英文名 GSK-189254 hydrochloride
中文别名
英文别名 GSK 189254A; GSK189254A; GSK-189254A; GSK 189254 HCl;
SMILES
化学名称
分子式 C21H25N3O2.HCl 分子量 387.91
纯度 98% 配送 惯例下常温包邮
产品描述 GSK-189,254 is a potent and selective H3-receptor inverse agonist developed by GlaxoSmithKline. It has subnanomolar affinity for the H3 receptor (Ki 0.2nM) and selectivity of over 10,000x for H3 over other histamine receptor subtypes.Animal studies have shown it to possess not only stimulant and nootropic effects, but also analgesic action suggesting a role for H3 receptors in pain processing in the spinal cord. GSK-189,254 and several other related drugs are currently being investigated as a treatment for Alzheimer's disease and other forms of dementia, as well as possible use in the treatment of conditions such as narcolepsy, or neuropathic pain which do not respond well to conventional analgesic drugs.
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