坎格列净半水合物

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09300CAS号：928672-86-0纯度：98%

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CAS号	928672-86-0	货号	BCP09300
中文名	坎格列净半水合物
英文名	Canagliflozin hemihydrate
中文别名	卡格列净半水合物;
英文别名	JNJ-24831754-ZAE; JNJ-28431754-AAA; JNJ 28431754 hemihydrate; JNJ-28431754 hemihydrate; JNJ28431754 hemihydrate; TA 7284 hemihydrate; TA-7284 hemihydrate; TA7284 hemihydrate;
SMILES	CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F.O
化学名称
分子式	2(C24H25FO5S).H2O	分子量	907.05
纯度	98%	配送	惯例下常温包邮
产品描述	Canagliflozin hemihydrate is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM, exhibits 413-fold selectivity over hSGLT1.Canagliflozin, also known as JNJ-28431754 and TA 7284, is a drug of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reabsorption (SGLT1 being responsible for the remaining 10%). Blocking this transporter causes up to 119 grams of blood glucose per day to be eliminated through the urine, corresponding to 476 kilocalories. Additional water is eliminated by osmotic diuresis, resulting in a lowering of blood pressure.