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| CAS号 | 865608-11-3 | 货号 | BCP37871 |
| 中文名 | CMPD101 | ||
| 英文名 | CMPD101 | ||
| 中文别名 | |||
| 英文别名 | CMPD 101; CMPD-101; Takeda101; Takeda-101; Takeda 101; | ||
| SMILES | CN1C(=NN=C1C2=CC=NC=C2)CNC3=CC=CC(=C3)C(=O)NCC4=CC=CC=C4C(F)(F)F | ||
| 化学名称 | |||
| 分子式 | C24H21F3N6O | 分子量 | 466.47 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | CMPD101 is a novel, potent and selective G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor (IC50 values are 35 and 32 nM at GRK2 and GRK3 respectively). CMPD101 exhibits selectivity for GRK2/3 over GRK1/5 and reduces DAMGO-induced desensitization and internalization of μ-opioid receptors. CMPD101 has been shown to potentiate phosphatidylinositol 4,5-bisphosphate (PIP2) depletion and slow agonist-induced desensitization of protease-activated receptor 2 (PAR2). | ||
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