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CAS号 | 38748-32-2 | 货号 | BCP01915 |
中文名 | 雷公藤甲素 | ||
英文名 | Triptolide | ||
中文别名 | 雷公藤内酯醇;雷公藤多甙; | ||
英文别名 | PG490;PG 490;PG-490; NSC163062; NSC-163062; NSC 163062; | ||
SMILES | |||
化学名称 | |||
分子式 | C20H24O6 | 分子量 | 360.41 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Triptolide is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties. Triptolide is shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. Triptolide inhibits the proliferation and colony formation of tumor cells at extremely low concentrations (2–10 ng/mL). Triptolide has an inhibitory activity on breast, stomach and leukemia cell line HL-60 cells. Triptolide induces apoptosis in tumor cells by blocking NF-κB activation and sensitizing tumor cells for TNF-&alpha induced programmed cell death. |
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