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CAS号 | 321839-75-2 | 货号 | BCP43623 |
中文名 | Crinecerfont hydrochloride | ||
英文名 | Crinecerfont hydrochloride | ||
中文别名 | |||
英文别名 | SSR 125543 hydrochloride;SSR 125543A; SR125543A; LS-150601; LS150601; LS 150601; | ||
SMILES | CC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F.Cl | ||
化学名称 | |||
分子式 | C27H29Cl2FN2OS | 分子量 | 519.5 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Crinecerfont is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein. SSR 125543A exhibited antidepressant and anxiolytic properties in the Flinders Sensitive Line rats. |
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