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CAS号 | 321695-57-2 | 货号 | BCP46453 |
中文名 | L002 | ||
英文名 | L002 | ||
中文别名 | |||
英文别名 | L 002;L-002; p300/CBP Inhibitor VI; NSC 764414; | ||
SMILES | CC1=CC(=NOS(=O)(=O)C2=CC=C(C=C2)OC)C=C(C1=O)C | ||
化学名称 | |||
分子式 | C15H15NO5S | 分子量 | 321.35 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | L-002 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment. |
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