MCC950 sodium 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP16648CAS号：256373-96-3纯度：98%

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CAS号	256373-96-3	货号	BCP16648
中文名	MCC950 sodium
英文名	MCC950 sodium
中文别名
英文别名	MCC 950 sodium;MCC-950 sodium;CP 45677 sodium;CP45677 sodium;CP-45677 sodium; CRID-3 sodium; CRID3 sodium; CRID 3 sodium; CP-456773 sodium salt;
SMILES
化学名称
分子式	C20H23N2NaO5S	分子量	426.46
纯度	98%	配送	惯例下常温包邮
产品描述	MCC950 sodium is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.MCC950, also known as CP-456773 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. MCC950 is a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease.