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CAS号 | 2089314-64-5 | 货号 | BCP49555 |
中文名 | AOH1996 | ||
英文名 | AOH1996 | ||
中文别名 | |||
英文别名 | AOH-1996;AOH 1996; | ||
SMILES | COC1=CC(=CC=C1)OC2=CC=CC=C2NC(=O)CNC(=O)C3=CC=CC4=CC=CC=C43 | ||
化学名称 | |||
分子式 | C26H22N2O4 | 分子量 | 426.46 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | AOH1996 is an orally active ligand of replisome component PCNA (Proliferating cell nuclear antigen), targeting to transcription-replication conflict (TRC). AOH1996 stabilizes the interaction of PCNA and RNA polymerase II, causing proteasome-dependent degradation of rpb1 and lethal DNA damages. AOH1996 also interferes the interaction of PCNA and its binding proteins, leading to DNA replication stress and inducing apoptosis. AOH1996 exerts synergistic effect with DNA damage agents, to inhibit tumor cells. |
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