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GNE-140 racemic 结构式

GNE-140 racemic

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货号 :BCP37998CAS号 :1809794-70-4纯度:98%
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  • 基本信息与产品描述
CAS号 1809794-70-4 货号 BCP37998
中文名 GNE-140 racemic
英文名 GNE-140 racemic
中文别名
英文别名 GNE140 racemic;GNE 140 racemic;
SMILES C1COCCN1C2=CC=C(C=C2)C3(CC(=C(C(=O)N3)SC4=CC=CC=C4Cl)O)C5=CSC=C5
化学名称
分子式 C25H23ClN2O3S2 分子量 499.04
纯度 98% 配送 惯例下常温包邮
产品描述 GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor. In MIA PaCa-2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE-140, but could be resensitized to GNE-140 with the OXPHOS inhibitor phenformin. Acquired resistance to GNE-140 was driven by activation of the AMPK-mTOR-S6K signaling pathway, which led to increased OXPHOS, and inhibitors targeting this pathway could prevent resistance.
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