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LDN-214117 结构式

LDN-214117

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货号 :BCP12392CAS号 :1627503-67-6纯度:98%
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  • 基本信息与产品描述
CAS号 1627503-67-6 货号 BCP12392
中文名 LDN-214117
英文名 LDN-214117
中文别名
英文别名 LDN214117;LDN 214117;
SMILES
化学名称
分子式 C25H29N3O3 分子量 419.52
纯度 98% 配送 惯例下常温包邮
产品描述 LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM, followed by TNIK, RIPK2, and ABL1. LDN-214117 has a cell-based IC50 for BMP6 of approximately 100 nM and 164-fold selectivity for BMP6 versus TGF-β1. Fibrodysplasia ossificans progressiva (FOP) is a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN-214117 had nearly identical binding affinity for wild-type ALK2 and each of the FOP-causing mutants tested.
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