Gartisertib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44100CAS号：1613191-99-3纯度：98%

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CAS号	1613191-99-3	货号	BCP44100
中文名	Gartisertib
英文名	Gartisertib
中文别名
英文别名	ATR inhibitor 2;M4344; M-4344; M 4344; VX-803; VX803; VX 803; Gartisertibum;
SMILES	C1CN(CCC1C(=O)N2CCN(CC2)C3COC3)C4=C(C=NC=C4NC(=O)C5=C6N=CC(=CN6N=C5N)F)F
化学名称
分子式	C25H29F2N9O3	分子量	541.55
纯度	98%	配送	惯例下常温包邮
产品描述	Gartisertib is an orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor VX-803 selectively inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, which results in the inhibition of DNA damage checkpoint activation, the disruption of DNA damage repair, and the induction of tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival; it is activated by DNA damage caused during DNA replication-associated stress.