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| CAS号 | 1232416-25-9 | 货号 | BCP07948 |
| 中文名 | VE-822 | ||
| 英文名 | VE-822 | ||
| 中文别名 | |||
| 英文别名 | VE822; VE 822; VX970; VX-970; VX 970; Berzosertib; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C24H25N5O3S | 分子量 | 463.55 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | VE-822, also known as VX-970 or Berzosertib, is an potent ATR inhibitor. VE-822 inhibited ATR in vitro and in vivo. VE-822 decreased maintenance of cell-cycle checkpoints, increased persistent DNA damage and decreased homologous recombination in irradiated cancer cells. VE-822 decreased survival of pancreatic cancer cells but not normal cells in response to XRT or gemcitabine. VE-822 markedly prolonged growth delay of pancreatic cancer xenografts after XRT and gemcitabine-based chemoradiation without augmenting normal cell or tissue toxicity. These findings support ATR inhibition as a promising new approach to improve the therapeutic ration of radiochemotherapy for patients with PDAC. | ||
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