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CAS号 | 1219927-22-6 | 货号 | BCP37822 |
中文名 | RO2959 Hydrochloride | ||
英文名 | RO2959 Hydrochloride | ||
中文别名 | |||
英文别名 | RO2959 HCl;RO 2959 HCl;RO-2959 HCl;RO-2959 Hydrochloride; | ||
SMILES | CC1=C(CN(CC1)C2=NC=C(S2)C)C3=CN=C(C=N3)NC(=O)C4=C(C=CC=C4F)F.Cl | ||
化学名称 | |||
分子式 | C21H20ClF2N5OS | 分子量 | 463.93 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways. |
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