福他替尼二钠盐新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02850CAS号：1025687-58-4纯度：98%

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CAS号	1025687-58-4	货号	BCP02850
关联产品	901119-35-5（福他替尼） 914295-16-2（福他替尼钠盐水合物）
中文名	福他替尼二钠盐
英文名	Fostamatinib disodium
中文别名	Fostamatinib 二钠盐;
英文别名	prodrug of R-406;R935788 sodium;R-788;R 788;R788 disodium;R935788; R-935788; R 935788;
SMILES	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
化学名称
分子式	C23H24FN6O9P.2Na	分子量	624.42
纯度	98%	配送	惯例下常温包邮
产品描述	Fostamatinib Disodium Anhydrous is the anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. R935788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. R406 (in vitro active form of R935788) selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM, more potently than Syk-independent pathways in different cells.R406 inhibits cellular proliferation of a variety of diffuse large B-cell lymphoma (DLBCL) cell lines with EC50 values ranging from 0.8 μM to 8.1 μM.R406 treatment reduces basal phosphorylation of BLNK, Akt, glycogen synthase kinase-3 (GSK-3), forkhead box O (FOXO) and ERK not only in cells with high (TCL-002) but also in cells with low levels of phosphorylated Syk (TCL1-551).

福他替尼二钠盐 新