PD 161570
| CAS No. | 192705-80-9 | Cat. No. | BCP24138 |
| Name | PD 161570 | ||
| Synonyms | PD 161570; PD161570; | ||
| Formula | C26H35Cl2N7O | M. Wt | 532.51 |
| Description | PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity toward the FGF-1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3.7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. The results demonstrate a novel synthetic inhibitor with nanomolar potency and specificity towards the FGF-1 receptor tyrosine kinase. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway TGF beta/Smad | ||
| Targets | BMP/TGF beta Receptor Src/Bcr Abl PDGFR EGFR | ||
Structure
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