TX-1918
| CAS No. | 503473-32-3 | Cat. No. | BCP16358 |
| Name | TX-1918 | ||
| Synonyms | TX 1918;TX1918; | ||
| Formula | C14H12O3 | M. Wt | 228.24 |
| Description | TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM). It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway GPCR/G Protein TGF beta/Smad Wnt/Stem Cell Epigenetics | ||
| Targets | Src/Bcr Abl EGFR PKA PKC | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.