Glycyl-H 1152 dihydrochloride
| CAS No. | 913844-45-8 | Cat. No. | BCP27782 |
| Name | Glycyl-H 1152 dihydrochloride | ||
| Synonyms | H-1152Glycyl, Dihydrochloride; Rho Kinase Inhibitor IV; | ||
| Formula | C18H24N4O3S.2HCl | M. Wt | 449.4 |
| Description | Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride with an improved selectivity for ROCKII (IC50 = 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC, respectively). Glycyl-H 1152 dihydrochloride is used for the treatment of hypertension and arteriosclerosis. | ||
| Pathways | Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell | ||
| Targets | ROCK | ||
Structure
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