Fingolimod HCl

CAS No.	162359-56-0	Cat. No.	BCP01808
Name	Fingolimod HCl
Synonyms	Fingolimod;Gilenia;FTY720; FTY-720; FTY 720;Fingolimod hydrochloride;
Formula	C19H33NO2.HCl	M. Wt	343.93

Description	The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720.Medium and high-dose FTY720-P also enhances the levels of TGF-β1. TGF-β1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group.
Pathways	Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage GPCR/G Protein
Targets	S1P Receptor Src/Bcr Abl PAK

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.

For product details of different batches, please contact our Customer

Products are for research use only and not for human use. We do not sell to patients.