GF109203X
| CAS No. | 133052-90-1 | Cat. No. | BCP08311 |
| Name | GF109203X | ||
| Synonyms | Bisindolylmaleimide I;GF 109203X;GF-109203X; | ||
| Formula | C25H24N4O2 | M. Wt | 412.49 |
| Description | GF109203X, as an ATP-competitive PKC inhibitor, prevents platelet aggregation induced by stimuli that activate PKC, and has the potential as a tool for studying the involvement of PKC in signal transduction pathways. GF 109203X produces reversal activity on P-glycoprotein and MRP -mediated multidrug resistance. PKC inhibition by GF109203X significantly reduces carbachol-stimulated ERK1/2 activation and the subsequent proliferation of SNU-407 colon cancer cells. | ||
| Pathways | TGF beta/Smad PI3K/Akt/mTOR Wnt/Stem Cell Epigenetics | ||
| Targets | GSK3 PKC | ||
Structure
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