比生群二盐酸盐
CAS号 | 71439-68-4 | 货号 | BCP46265 |
中文名 | 比生群二盐酸盐 | ||
英文名 | Bisantrene dihydrochloride | ||
中文别名 | |||
英文别名 | Bisantrene HCl;CL-216942; CL216942; CL 216942; | ||
分子式 | C22H24Cl2N8 | 分子量 | 471.39 |
生物活性 | Bisantrene is topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. | ||
上下游产品 | 78186-34-2(比生群) | ||
信号通路 | Cell Cycle/DNA Damage | ||
靶 点 | Topoisomerase |
结构式
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