TAS-115 mesylate

  • 化学数据
CAS号 1688673-09-7 货号 BCP34015
中文名 TAS-115 mesylate
英文名 TAS-115 mesylate
中文别名
英文别名 TAS 115 methanesulfonate;TAS-115 methanesulfonate;TAS115 mesylate;
分子式 C28H27FN4O7S2 分子量 614.66
  • 用途
生物活性 TAS-115 is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Met VEGFR 

结构式

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